Leukemia is the most common type encounteredin pediatric and adult patients. In acute leukemia, hematopoietic stem cells(HSCs) reside in specialized niche in the bone marrow (BM). These stem cells are thought to provide signals that support key HSC properties.Normality, cytokines regulate a variety of hematopoietic cell functions through the activation of multiple signal transduction pathways. In this regard, regulation of proliferation and differentiation of HSCs is related by the gene expression pattern in the cell and the composition of external signals from the BM niche.
Ahmad Reza Rahnemoon