Anastasios D Papanastasiou*, Martha Nifora, Zoi Stamou and Maria Repanti
Department of Pathology, Patras General Hospital, Patras, Greece
Received date: September 17, 2016; Accepted date: September 20, 2016; Published date: September 22, 2016
Citation: Papanastasiou AD, Nifora M, Stamou Z, et al. Primary Sarcomatoid Carcinoma of the Skin. Arch Can Res. 2016, 4: 3.
Skin primary sarcomatoid carcinomas (SPSCs) are rare cutaneous neoplasms and their derivation is challenging. SPSCs comprise a wide group of skin malignant neoplasms and differential diagnosis includes squamous cell carcinoma, melanoma, atypical fibroxanthoma, sarcoma as well as metastatic tumors
Skin primary sarcomatoid carcinomas (SPSCs) are rare cutaneous neoplasms and their derivation is challenging [1,2]. SPSCs comprise a wide group of skin malignant neoplasms and differential diagnosis includes squamous cell carcinoma, melanoma, atypical fibroxanthoma, sarcoma as well as metastatic tumors [3,4] (Figure 1).
A 44-year-old woman presented with a crateriform ulcerated, rapidly growing tumor on her left thigh, 1.3 cm in its greatest dimension. The tumor was composed of spindle cells with marked nuclear atypia and pleomorphism. Multinucleated tumor giant cells were observed while necrosis was prominent and atypical mitotic figures numerous. No glandular formation or other conspicuous cell arrangement was observed. A benign adnexal tumor or foci of well differentiated carcinoma was not identified and this was attributed to the fact that the lesion was ulcerated and partially necrotic.
By immunohistochemistry, the malignant spindle cells in the specimen stained diffusely positive for cytokeratins (AE1/AE3, CAM5.2, CK7), vimentin and p16, while EMA, Smooth Muscle Actin (SMA), CD163, p53 and D2-40 were focally positive. CK20, p63, HMB45 and Desmin were negative in the malignant cell population.
The histological and immunohistochemical findings in conjunction with p16 and D2-40 immunoreactivity, points to a diagnosis of a primary sarcomatoid carcinoma of the skin, probably of eccrine derivation.
Part of this work has been previously presented as a poster at the ESP Conference 2015 (PS-11-043).