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Anti-Cancer Effect of UV Irradiation at Presence of Cadmium Oxide (CdO) Nanoparticles on DNA of Cancer Cells: A Photodynamic Therapy Study

A Heidari*
Faculty of Chemistry, California South University
*Corresponding Author: A Heidari, Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA, E-mail: Scholar.Researcher.Scientist@gmail.com
Received: March 22, 2016; Accepted: March 24, 2016; Published: March 28, 2016
Citation: Heidari A. Anti-Cancer Effect of UV Irradiation at Presence of Cadmium Oxide (CdO) Nanoparticles on DNA of Cancer Cells: A Photodynamic Therapy Study. Arch Cancer Res. 2016, 4:1.
 
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Abstract

Due to the extensive usage of anti-cancers, the spread of multidrug resistant DNA of cancer cells is one of the most worrying threats to public health. In this editorial, the susceptibility of DNA of cancer cells to inactivation by a novel treatment, which involves applying appropriate UV irradiation at presence of Cadmium Oxide (CdO) nanoparticles on DNA of cancer cells, as a promising method for medical, clinical, biological, pharmaceutical, biochemical and photodynamic applications were analyzed.

Editorial

Due to the extensive usage of anti-cancers, the spread of multidrug resistant DNA of cancer cells is one of the most worrying threats to public health. In this editorial, the susceptibility of DNA of cancer cells to inactivation by a novel treatment, which involves applying appropriate UV irradiation at presence of Cadmium Oxide (CdO) nanoparticles, on DNA of cancer cells, as a promising method for medical, clinical, biological, pharmaceutical, biochemical and photodynamic applications were analyzed.
A series of in vitro experiments have been designed to investigate DNA of cancer cells sensitivity to different anti-cancer agents such as UV irradiation and Cadmium Oxide (CdO) nanoparticles constructed by laser ablation and chemical reaction [1-4]. Different processes of Cadmium Oxide (CdO) nanoparticles production led to different size distribution and contact cross section; the nanoparticles with size distribution of 10 (nm) to 85 (nm) were used at this editorial.
UV irradiation and Cadmium Oxide (CdO) nanoparticles with concentration of several micromoles, which have produced through chemical reaction, was lonely eliminated DNA of cancer cells. Cadmium Oxide (CdO) nanoparticles that were produced by laser ablation have not any anti-cancer effect at high concentration. By coupling these two agents, UV irradiation at the presence of Cadmium Oxide (CdO) nanoparticles, the DNA of cancer cells were high eliminated after about 15 (min) of exposure and interestingly the high concentration of Cadmium Oxide (CdO) nanoparticles were enough for this purpose. Cadmium Oxide (CdO) nanoparticles, which produced by laser ablation process, also were able to effectively eliminate the DNA of cancer cells at the presence of UV irradiation in short time that was much less than previous reports [5-24].
According to several researches that were dealt on the effect of irradiation of UV on DNA of cancer cells, we developed a new method for eliminating of DNA of cancer cells by applying both Cadmium Oxide (CdO) nanoparticles and UV irradiation, which involve using a high concentration of Cadmium Oxide (CdO) nanoparticles at the presence of UV irradiation in short time irradiation. Production of Protoporphyrin IX, Methyl Aminolevulinate and Protoporphyrin have been suggested as a probable reason of DNA death by this treatment. An appropriate does of Cadmium Oxide (CdO) nanoparticles led to DNA death through several mechanisms, which include free radical production near it and pits creation in DNA of cancer cells. According to our experiment, applying a higher concentration of Cadmium Oxide (CdO) nanoparticles at the presence of UV irradiation may represent a novel method for eliminating of DNA of cancer cells, particularly in patients who have failed current medical, clinical, biological, pharmaceutical, biochemical and photodynamic treatments.

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